Archive | Alzheimer’s

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Vitamin K2: Optimal Levels Essential for the Prevention of Age-Associated Chronic Disease

Abstract Sufficiency of vitamin K, as K2 specifically, is gaining recognition as a requirement for long term health in many more areas of human physiology than previously realized. The breaking research is revealing a number of roles for vitamin K reaching well beyond coagulation to not only long term cardiovascular and skeletal health, but that […]

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Amyloidogenic and Non-Amyloidogenic APP Processing

Alzheimer’s and Atherosclerosis – Siblings in a Dysfunctional Family: Part I

Abstract Amyloid precursor protein (APP) is the transmembrane protein that, if cleaved by the enzyme beta-secretase, produces amyloid beta (the histopathological hallmark of Alzheimer’s disease [AD]). If acted upon by the enzyme alpha-secretase, however, APP cleavage produces neuroprotective compounds.  What determines which enzyme will gain access to APP? The answers to this question reveal connections […]

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Getting off the Alzheimer’s Disease Interstate: Part II

Abstract Despite extensive efforts to identify a magic bullet to prevent the occurrence or mitigate the progression of Alzheimer’s disease (AD), no effective single “pill-for-an-ill” strategy has been found, which is likely why on April 28, 2010, an NIH consensus panel on AD prevention pronounced, “There is no good evidence that Alzheimer’s disease or the […]

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Lara Pizzorno

Beyond α-Tocopherol: A Review of Natural Vitamin E’s Therapeutic Potential in Human Health and Disease: Part I

Abstract A widely reported meta-analysis, published in the Annals of Internal Medicine in 2005, found that, while doses of vitamin E < 200 IU had no negative effects, high-dose vitamin E, defined as ≥ 400 IU per day, resulted in a small but significant (4%) increase in all-cause mortality. Despite the uncritical press coverage given […]

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Amyloid Plaque

Alzheimer’s Disease: a 21st Century Epidemic

Abstract Accumulation of amyloid plaque is a common feature not only in Alzheimer’s disease (AD), Creutzfeldt-Jakob Disease (aka Mad Cow disease), and the dementias associated with Parkinson’s disease and Huntington’s disease, but in the aging brain, brain injury, and certain chronic low grade infections, such as Lyme disease. Amyloid-beta (Abeta or Aβ), a peptide of […]

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