Archive | Atherosclerosis

Amyloidogenic and Non-Amyloidogenic APP Processing

Alzheimer’s and Atherosclerosis – Siblings in a Dysfunctional Family: Part I

Abstract Amyloid precursor protein (APP) is the transmembrane protein that, if cleaved by the enzyme beta-secretase, produces amyloid beta (the histopathological hallmark of Alzheimer’s disease [AD]). If acted upon by the enzyme alpha-secretase, however, APP cleavage produces neuroprotective compounds.  What determines which enzyme will gain access to APP? The answers to this question reveal connections […]

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