by Lara Pizzorno, MDiv, MA, LMT with Barry Wheeler, ND Treating the sequelae of andropause, the age- and stress-related decline in hormones in the adult male, with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality ...
by Lara Pizzorno, MDiv, MA, LMT, with Pushpa Larsen, ND Part I: The Advantages and Disadvantages of Saliva, Serum and Urine Tests Treating the sequelae of the age- and stress-related decline in adult hormones with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, […]
by Lara Pizzorno, MDiv, MA, LMT with Barry Wheeler, ND Treating the sequelae of andropause, the age- and stress-related decline in hormones in the adult male, with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality of life. Successful and safe […]
Abstract Sufficiency of vitamin K, as K2 specifically, is gaining recognition as a requirement for long term health in many more areas of human physiology than previously realized. The breaking research is revealing a number of roles for vitamin K reaching well beyond coagulation to not only long term cardiovascular and skeletal health, but that […]
A meta-analysis published in the July 29, 2010 issue of the British Medical Journal1 deserves special mention for exemplifying—to the point that one wonders if the subtext is to point out the idiocy of our current research paradigm—the shortcomings of the “isolate one variable” approach to studying human physiology or providing dietary supplements for real […]
Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]
Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]
Abstract Amyloid precursor protein (APP) is the transmembrane protein that, if cleaved by the enzyme beta-secretase, produces amyloid beta (the histopathological hallmark of Alzheimer’s disease [AD]). If acted upon by the enzyme alpha-secretase, however, APP cleavage produces neuroprotective compounds. What determines which enzyme will gain access to APP? The answers to this question reveal connections […]
Abstract Despite extensive efforts to identify a magic bullet to prevent the occurrence or mitigate the progression of Alzheimer’s disease (AD), no effective single “pill-for-an-ill” strategy has been found, which is likely why on April 28, 2010, an NIH consensus panel on AD prevention pronounced, “There is no good evidence that Alzheimer’s disease or the […]
Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the […]
Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by […]
Part III: Restoring Mitophagy – the Key To Mitochondrial Rejuvenation Introduction Mitochondrial decay resulting from oxidative damage accumulates with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Part I of this review discussed Bruce […]
Part II: The Methylation – Transsulfuration Connection to Mitochond Introduction Mitochondrial decay resulting from oxidative damage accumulates with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Part I of this review discussed Bruce Ames’ […]
Part I: Delaying the Mitochondrial Decay of Aging Introduction Mitochondrial decay resulting from oxidative damage is known to accumulate with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Age-associated changes in mitochondria are characterized […]
Cardiovascular disease, which now afflicts more than 80 million Americans – 36.3% of the U.S. population, including 38,100,000 individuals ≥ 60 – continues to be the No. 1 cause of death in the U.S., despite widespread use of statins, which, in 2002, were being taken by >30% of Medicare patients ≥ 65.1 Statins, the most […]
Women are at risk of vitamin A deficiency. In his presentation at the 2nd Hohenheim Nutrition Conference in Stuttgart, Germany, November 2009, Dr. Georg Lietz of England’s Newcastle University, the senior investigator in research published April 2009 in the FASEB Journal (and summarized in our June 2009 LMR review, “Vitamin A – Tolerance Extends Longevity”), […]
Introduction As primary prevention for a myocardial infarction or stroke, you’ve prescribed a statin, possibly in conjunction with a fibrate, for a 50 year old male patient with one or more of the following: metabolic syndrome, type 2 diabetes, hypercholesterolemia, coronary artery disease or peripheral artery disease. In a follow-up visit, his PSA is elevated, […]
Clarification is in order for the widely publicized findings of a recent BMJ article entitled: Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of the hip or knee: network meta-analysis.1 The headline of the September 13, 2010, press release declaims: Popular supplements to combat joint pain do not work.2 Since numerous studies, including […]
Abstract Vitamin A is a family of essential fat-soluble dietary compounds, three of which—retinol, retinal and retinoic acid—play significant roles in the human body, with each compound performing functions the others cannot. Retinol is the major transport and storage form of vitamin A; retinal is essential for vision, and retinoic acid acts like a hormone, […]
Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]
Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]
