Abstract A widely reported meta-analysis, published in the Annals of Internal Medicine in 2005, found that, while doses of vitamin E < 200 IU had no negative effects, high-dose vitamin E, defined as ≥ 400 IU per day, resulted in a small but significant (4%) increase in all-cause mortality. Despite the uncritical press coverage given […]
A member of many Scientific Societies, Dr. Bill Cham is frequently invited to speak at Conferences on his research topics. His research interests cover a wide range of disciplines resulting in publications of over a hundred articles on topics ranging from pharmacology, iron metabolism, mineral research, lipidology and oncology. His research in lipidology starting from […]
Abstract Accumulation of amyloid plaque is a common feature not only in Alzheimer’s disease (AD), Creutzfeldt-Jakob Disease (aka Mad Cow disease), and the dementias associated with Parkinson’s disease and Huntington’s disease, but in the aging brain, brain injury, and certain chronic low grade infections, such as Lyme disease. Amyloid-beta (Abeta or Aβ), a peptide of […]
(adapted from Mavericks of Medicine, Smart Publications) Joseph Knoll, M.D., a Hungarian neurochemist and pharmacologist probably best known for developing the drug deprenyl (Selegiline), the first selective monoamine oxidase-B (MAO-B) inhibitor, has researched its properties for more than half a century. Dr. Knoll’s recently published book, The Brain and Its Self: A Neurochemical Concept of […]
Abstract Advanced glycated end-products (AGEs) form as a result of a non-enzymatic reaction in which glucose forms adducts with proteins, lipids and nucleic acids. AGEs accumulate naturally as a result of chronological aging, but this process is greatly accelerated under conditions of hyperglycemia and oxidative stress. AGEs directly induce cross-linking of long-lived proteins, such as […]
