Abstract Cellular senescence, although protective when triggered in cells that have become cancerous, plays a key pathological role in other age-associated diseases and in so-called “healthy aging.” The age-associated increase in cellular senescence has been assumed to result from the cumulative effects of “wear and tear,” but genetic research has revealed that cellular senescence occurs […]
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New Developments in Cannabinoid-Based Medicine: An Interview with Dr. Raphael Mechoulam
(adapted from Mavericks of Medicine by David Jay Brown) Raphael Mechoulam, Ph.D., is the Lionel Jacobson Professor of Medicinal Chemistry at the Hebrew University of Jerusalem, where he has been working on cannabinoid chemistry (a term he coined) for more than forty years. Dr. Mechoulam is recognized as one of the world’s experts on cannabinoid-based […]
Management of Adult Growth Hormone Deficiency: Safe and Effective
Abstract Progressive pituitary hormone deficiency is characteristic of aging, and the hypothalamic-GH-IGF-I axis is the first hormonal system affected. Daily GH secretion peaks around puberty, begins to decline by age 21, and by age 60, most adults have total 24-hour GH secretion rates indistinguishable from those of hypopituitary patients with organic lesions in the pituitary […]