Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]
Clarification is in order for the widely publicized findings of a recent BMJ article entitled: Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of the hip or knee: network meta-analysis.1 The headline of the September 13, 2010, press release declaims: Popular supplements to combat joint pain do not work.2 Since numerous studies, including […]
Part II: Strong Bones for Life, Naturally Bone is dynamic, living tissue that is constantly being broken down and rebuilt, even in aging adults. Although insufficient dietary calcium and the postmenopausal drop in estrogen have been singled out as the only issues, osteoporosis involves much more than simply a lack of these factors. Normal bone […]
Abstract The most recent statistics indicate that dietary intake of omega-3 PUFA is insufficient in >95% of Americans. Deficits in omega-3s have been shown to contribute to inflammatory signaling, apoptosis, and neuronal dysfunction in all cause dementia, including Alzheimer’s disease. DHA (22:6[n-3]), specifically, is a critical contributor to cell structure and function in the nervous […]
Introduction Telomeres, the protective DNA–protein complexes at the end of chromosomes, are required for DNA replication and to protect chromosomes from nuclease degradation, end-to-end fusion, and the initiation of cellular senescence. Since telomeres shorten with each cell division, telomere length is a key indicator of mitotic cell aging and viability. Telomere length has emerged as […]
