Introduction Telomeres, the protective DNA–protein complexes at the end of chromosomes, are required for DNA replication and to protect chromosomes from nuclease degradation, end-to-end fusion, and the initiation of cellular senescence. Since telomeres shorten with each cell division, telomere length is a key indicator of mitotic cell aging and viability. Telomere length has emerged as […]
Nonsteriodal anti-inflammatory drugs (NSAIDs), including aspirin, are commonly used for pain relief, have consistently been shown to reduce the risk of cancers, and low-dose aspirin is effective in reducing cardiovascular disease risk because of its antithrombotic effect. However, the long-term use of aspirin and other NSAIDs has been hindered by their associated adverse effects, including […]
Functional Medicine: A 21st Century Systems Biology Approach to Individualized Clinical Care. Dr. Mark Hyman’s latest book, The UltraMind Solution (Scribner’s, 2009) presents a highly convincing argument, backed by hundreds of peer-reviewed studies published within the last five years, for the validity of a functional medicine approach to treating brain disorders of all types. Functional […]
Abstract Cellular senescence, although protective when triggered in cells that have become cancerous, plays a key pathological role in other age-associated diseases and in so-called “healthy aging.” The age-associated increase in cellular senescence has been assumed to result from the cumulative effects of “wear and tear,” but genetic research has revealed that cellular senescence occurs […]
Abstract Cellular senescence, although protective when triggered in cells that have become cancerous, plays a key pathological role in other age-associated diseases and in so-called “healthy aging.” The age-associated increase in cellular senescence has been assumed to result from the cumulative effects of “wear and tear,” but genetic research has revealed that cellular senescence occurs […]
