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    Bio-Identical Hormone Replacement: Selecting the Right Hormone Test(s) for Your Male Patient

    by Lara Pizzorno, MDiv, MA, LMT with Barry Wheeler, ND Treating the sequelae of andropause, the age- and stress-related decline in hormones in the adult male, with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality ...

Testing

Ensure Effective Bio-Identical Hormone Replacement: Select the Right Hormone Test for Your Patient

by Lara Pizzorno, MDiv, MA, LMT, with Pushpa Larsen, ND Part I: The Advantages and Disadvantages of Saliva, Serum and Urine Tests Treating the sequelae of the age- and stress-related decline in adult hormones with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, […]

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Blood Tests

Bio-Identical Hormone Replacement: Selecting the Right Hormone Test(s) for Your Male Patient

by Lara Pizzorno, MDiv, MA, LMT with Barry Wheeler, ND Treating the sequelae of andropause, the age- and stress-related decline in hormones in the adult male, with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality of life. Successful and safe […]

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Office Visit

Vitamin K2: Optimal Levels Essential for the Prevention of Age-Associated Chronic Disease

Abstract Sufficiency of vitamin K, as K2 specifically, is gaining recognition as a requirement for long term health in many more areas of human physiology than previously realized. The breaking research is revealing a number of roles for vitamin K reaching well beyond coagulation to not only long term cardiovascular and skeletal health, but that […]

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Vitamin K2 Structure

Calcium Supplements Increase Risk of MI—The “One Variable” Emperor is Naked

A meta-analysis published in the July 29, 2010 issue of the British Medical Journal1  deserves special mention for exemplifying—to the point that one wonders if the subtext is to point out the idiocy of our current research paradigm—the shortcomings of the “isolate one variable” approach to studying human physiology or providing dietary supplements for real […]

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Sirtuin Deacetylation Reaction

Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part I

Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]

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Resveratrol Mitochondria Chart

Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part II

Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]

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Amyloidogenic and Non-Amyloidogenic APP Processing

Alzheimer’s and Atherosclerosis – Siblings in a Dysfunctional Family: Part I

Abstract Amyloid precursor protein (APP) is the transmembrane protein that, if cleaved by the enzyme beta-secretase, produces amyloid beta (the histopathological hallmark of Alzheimer’s disease [AD]). If acted upon by the enzyme alpha-secretase, however, APP cleavage produces neuroprotective compounds.  What determines which enzyme will gain access to APP? The answers to this question reveal connections […]

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brainwave

Getting off the Alzheimer’s Disease Interstate: Part II

Abstract Despite extensive efforts to identify a magic bullet to prevent the occurrence or mitigate the progression of Alzheimer’s disease (AD), no effective single “pill-for-an-ill” strategy has been found, which is likely why on April 28, 2010, an NIH consensus panel on AD prevention pronounced, “There is no good evidence that Alzheimer’s disease or the […]

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Cardio

Vitamin D and Vitamin K Team Up to Lower CVD Risk: Part I

Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the […]

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Cardio MAn

Vitamin D and Vitamin K Team Up to Lower CVD Risk: Part II

Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by […]

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A vicious cycle drives mitochondrial decay in aging

Beyond the Mitochondrial Tune Up: Part III

Part III: Restoring Mitophagy – the Key To Mitochondrial Rejuvenation Introduction Mitochondrial decay resulting from oxidative damage accumulates with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Part I of this review discussed Bruce […]

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Mitochondrial Oxidative Phosphorylation (Electron Transport Chain)

Beyond the Mitochondrial Tune Up: Part II

Part II: The Methylation – Transsulfuration Connection to Mitochond Introduction Mitochondrial decay resulting from oxidative damage accumulates with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Part I of this review discussed Bruce Ames’ […]

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Krebs Cycle

Beyond the Mitochondrial Tune Up: Part I

Part I: Delaying the Mitochondrial Decay of Aging Introduction Mitochondrial decay resulting from oxidative damage is known to accumulate with age and is universally recognized as a major contributing factor to the whole range of functional decline and tissue deterioration associated with aging.1 2 3 4 5 6 7 Age-associated changes in mitochondria are characterized […]

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Cardioprotective Strategies to Close the Statin Gap: “News to Use” from the Latest Research

Cardiovascular disease, which now afflicts more than 80 million Americans – 36.3% of the U.S. population, including 38,100,000 individuals ≥ 60 – continues to be the No. 1 cause of death in the U.S., despite widespread use of statins, which, in 2002,  were being taken by >30% of Medicare patients ≥ 65.1 Statins, the most […]

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Common Genetic Variants and Other Host-related Factors Greatly Increase Susceptibility to Vitamin A Deficiency

Women are at risk of vitamin A deficiency. In his presentation at the 2nd Hohenheim Nutrition Conference in Stuttgart, Germany, November 2009, Dr. Georg Lietz of England’s Newcastle University, the senior investigator in research published April 2009 in the FASEB Journal (and summarized in our June 2009 LMR review, “Vitamin A – Tolerance Extends Longevity”), […]

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Erectile Dysfunction as an Adverse Drug Reaction

Introduction As primary prevention for a myocardial infarction or stroke, you’ve prescribed a statin, possibly in conjunction with a fibrate, for a 50 year old male patient with one or more of the following: metabolic syndrome, type 2 diabetes, hypercholesterolemia, coronary artery disease or peripheral artery disease. In a follow-up visit, his PSA is elevated, […]

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Joint Pain

Glucosamine sulphate, but not glucosamine hydrochloride, effective against osteoarthritis

Clarification is in order for the widely publicized findings of a recent BMJ article entitled: Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of the hip or knee: network meta-analysis.1 The headline of the September 13, 2010, press release declaims: Popular supplements to combat joint pain do not work.2 Since numerous studies, including […]

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Vitamin A Regulation

Vitamin A – Tolerance Extends Longevity

Abstract Vitamin A is a family of essential fat-soluble dietary compounds, three of which—retinol, retinal and retinoic acid—play significant roles in the human body, with each compound performing functions the others cannot. Retinol is the major transport and storage form of vitamin A; retinal is essential for vision, and retinoic acid acts like a hormone, […]

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Iodine: the Next Vitamin D? Part II

Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]

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Iodine: the Next Vitamin D? Part I

Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]

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