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  • Resveratrol Mitochondria Chart

    Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part II

    Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, ...

Sirtuin Deacetylation Reaction

Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part I

Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]

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Resveratrol Mitochondria Chart

Resveratrol, Niacin, Nicotinamide Riboside: Key Players in Activating Sirtuins to Mimic Calorie Restriction & Extend Lifespan, Part II

Abstract In just the last 30 years, molecular biologists have discovered genes with the potential to extend longevity: SIR2 in yeast and its mammalian equivalent, SIRT1. In animal models, SIRT1, via the enzymes it encodes, has been shown to have healthspan extending regulatory effects on metabolism, stress resistance, cellular survival, cellular senescence, inflammation-immune function, endothelial […]

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Vitamin A Regulation

Vitamin A – Tolerance Extends Longevity

Abstract Vitamin A is a family of essential fat-soluble dietary compounds, three of which—retinol, retinal and retinoic acid—play significant roles in the human body, with each compound performing functions the others cannot. Retinol is the major transport and storage form of vitamin A; retinal is essential for vision, and retinoic acid acts like a hormone, […]

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Cardio MAn

Vitamin D and Vitamin K Team Up to Lower CVD Risk: Part II

Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by […]

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Cardio

Vitamin D and Vitamin K Team Up to Lower CVD Risk: Part I

Abstract Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the […]

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Iodine: the Next Vitamin D? Part II

Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]

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Iodine: the Next Vitamin D? Part I

Abstract Despite the widely held assumption that Americans are iodine-sufficient due to the availability of iodized salt, the U.S. population is actually at high risk for iodine insufficiency. Iodine intake has been decreasing in the U.S. since the early 70s as a result of changes in Americans’ food and dietary habits, including the facts that […]

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Vitamin K2 Structure

Calcium Supplements Increase Risk of MI—The “One Variable” Emperor is Naked

A meta-analysis published in the July 29, 2010 issue of the British Medical Journal1  deserves special mention for exemplifying—to the point that one wonders if the subtext is to point out the idiocy of our current research paradigm—the shortcomings of the “isolate one variable” approach to studying human physiology or providing dietary supplements for real […]

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Testing

Ensure Effective Bio-Identical Hormone Replacement: Select the Right Hormone Test for Your Patient

by Lara Pizzorno, MDiv, MA, LMT, with Pushpa Larsen, ND Part I: The Advantages and Disadvantages of Saliva, Serum and Urine Tests Treating the sequelae of the age- and stress-related decline in adult hormones with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, […]

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Blood Tests

Bio-Identical Hormone Replacement: Selecting the Right Hormone Test(s) for Your Male Patient

by Lara Pizzorno, MDiv, MA, LMT with Barry Wheeler, ND Treating the sequelae of andropause, the age- and stress-related decline in hormones in the adult male, with bio-identical hormone replacement (BHRT) can restore more youthful hormone levels and significantly alleviate symptoms associated with “normal” aging, optimizing health, happiness and quality of life. Successful and safe […]

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